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DeCS
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Descriptor English:
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Zidovudine
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Descriptor Spanish:
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Zidovudina
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Descriptor Portuguese:
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Zidovudina
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Synonyms English:
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3'-Azido-2',3'-Dideoxythymidine
3'-Azido-3'-deoxythymidine
AZT Antiviral
AZT, Antiviral
BW A509U
BWA-509U
Retrovir
3' Azido 2',3' Dideoxythymidine
3' Azido 3' deoxythymidine
Antiviral AZT
BWA 509U
BWA509U
Azidothymidine
AZT (Antiviral)
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Tree Number:
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D03.383.742.680.705.950
D13.570.230.500.950
D13.570.230.855.950
D13.570.685.705.950
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Definition English:
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A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse transcription. It improves immunologic function, partially reverses the HIV-induced neurological dysfunction, and improves certain other clinical abnormalities associated with AIDS. Its principal toxic effect is dose-dependent suppression of bone marrow, resulting in anemia and leukopenia. |
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Pharmacological Action:
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Anti-HIV Agents
Antimetabolites
Reverse Transcriptase Inhibitors
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History Note English:
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89
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Allowable Qualifiers English:
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Record Number:
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23867
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Unique Identifier:
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D015215
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Occurrence in VHL:
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Similar:
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DeCS CID-10 SciELO LILACS LIS
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